Amenorrhea is the lack of menstruation, which is commonly described as missing one or more menstrual cycles.
Primary amenorrhea is the lack of menstruation in a woman who has not had a period by the age of 15. The most prevalent causes of primary amenorrhea are hormonal imbalances, though anatomical issues can also induce amenorrhea.
Secondary amenorrhea is the absence of three or more periods in a row by someone who has previously had periods. Secondary amenorrhea is most commonly caused by pregnancy, however hormone issues can also cause it.
The treatment of amenorrhea is determined on the underlying cause.
WHAT ARE THE SYMPTOMS OF AMENORRHEA?
- Nipple discharge that is milky
- Loss of hair
- Headache
- Vision changes
- Excessive facial hair
- Pelvic pain
- Acne
WHAT ARE THE CAUSES OF AMENORRHEA?
Natural amenorrhea
- Pregnancy
- Breastfeeding
- Menopause
Contraceptives
Medications
- Antipsychotics
- Chemotherapy for cancer
- Antidepressants
- Blood pressure medications
- Medication for allergies
Lifestyle factors
Amenorrhea can be caused by a variety of lifestyle variables, including:
- Low body weight: Excessively low body weight — roughly 10% of normal weight — disrupts several hormonal activities in the body, perhaps preventing ovulation. Women suffering from an eating disorder, such as anorexia or bulimia, frequently stop having periods as a result of these aberrant hormonal changes.
- Excessive physical activity: Women who engage in strenuous training activities, such as ballet, may have their menstrual cycles disrupted. Athletes lose periods due to a combination of circumstances, including low body fat, stress, and high energy consumption.
- Stress: Mental stress can temporarily disrupt the functioning of your hypothalamus, a region of your brain that regulates the hormones that govern your menstrual cycle. As a result, ovulation and menstruation may cease. Regular menstrual periods usually resume once your stress levels have decreased.
Hormonal imbalance
Hormonal imbalance can be caused by a variety of medical issues, including:
Polycystic ovary syndrome (PCOS): PCOS results in relatively high and prolonged hormone levels, as opposed to the variable levels seen in the typical menstrual cycle.
Thyroid malfunction: Menstrual abnormalities, including amenorrhea, can be caused by an overactive thyroid gland (hyperthyroidism) or an underactive thyroid gland (hypothyroidism).
Pituitary tumor: A noncancerous (benign) pituitary tumor can disrupt the hormonal regulation of menstruation.
Premature menopause: Menopause often begins around the age of 50. However, for some women, the ovarian supply of eggs declines before the age of 40, and menstruation ceases.
Structural issues
Amenorrhea can also be caused by problems with the sexual organs. Here are several examples:
- Uterine scarring: Asherman's syndrome, a disorder in which scar tissue forms in the uterine lining, can arise following a dilation and curettage (D&C), cesarean section, or therapy for uterine fibroids. Uterine scarring inhibits the uterine lining from forming and shedding normally.
- The lack of reproductive organs: During fetal development, abnormalities can arise that result in missing elements of the reproductive system, such as the uterus, cervix, or vagina. Menstrual periods are not possible later in life because the reproductive system did not fully develop.
- Vaginal structural abnormalities: A vaginal blockage may impede noticeable menstrual bleeding. There may be a membrane or wall in the vagina that prevents blood from leaving the uterus and cervix.
WHAT ARE THE RISK FACTORS FOR AMENORRHEA?
- Family history: If other women in your family have had amenorrhea, you may have inherited a susceptibility to the condition.
- Eating problems: You are more likely to develop amenorrhea if you have an eating disorder, such as anorexia or bulimia.
- Athletic training: Athletic training can raise your chance of amenorrhea.
- History of some gynecologic procedures: If you've had a D&C, particularly one connected to pregnancy, or a technique known as loop electrodiathermy excision procedure (LEEP), you're more likely to develop amenorrhea.
WHAT ARE THE COMPLICATIONS OF AMENORRHEA?
- Infertility and pregnancy complications: You cannot become pregnant if you do not ovulate and do not have monthly cycles. When hormone imbalance is the cause of amenorrhea, it can potentially lead to miscarriage or other pregnancy complications.
- Psychological stress: It can be distressing to not have periods when your contemporaries do, especially for young individuals transitioning into adulthood.
- Cardiovascular disease and osteoporosis: These two issues can be caused by a lack of estrogen. Osteoporosis is a bone weakening condition. Cardiovascular illness encompasses heart attacks as well as blood vessel and heart muscle issues.
- Pelvic discomfort: If the amenorrhea is caused by an anatomical condition, it may also produce pelvic pain.
HOW IS AMENORRHEA DIAGNOSED?
Tests
- Pregnancy test: This is most likely the first test your doctor will recommend to rule out or confirm a probable pregnancy.
- Thyroid function test: Thyroid-stimulating hormone (TSH) levels in the blood can indicate whether or not your thyroid is functioning normally.
- Ovary function test: The level of follicle-stimulating hormone (FSH) in your blood can indicate whether or not your ovaries are functioning properly.
- Prolactin test: Prolactin levels that are low may indicate a pituitary gland malignancy.
- Male hormone test: If you have growing facial hair and a lower voice, your doctor may want to evaluate your blood levels of male hormones.
Hormone challenge test
Imaging tests
- Ultrasound: This test generates images of internal organs using sound waves. If you have never had a period, your doctor may advise you to get an ultrasound to look for any abnormalities in your reproductive organs.
- Magnetic resonance imaging (MRI): MRI produces extremely detailed images of soft tissues within the body by combining radio waves with a strong magnetic field. An MRI may be ordered by your doctor to look for a pituitary tumor.